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It is not known if bempedoic acid can lower the risk of complications related to high cholesterol (such as heart problems, heart attack, stroke, or death). Other drugs may affect bempedoic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Uses: As an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in those requiring additional LDL-C lowering. Another five deaths were cardiovascular-related, with most events occurring within the first 60 days. Tell your doctor right away if you become pregnant. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. In addition, the price that Esperion plans to charge for bempedoic acid is not much lower than the price that Express Scripts apparently is getting from Regeneron for Praluent. Register Today. Reproduction in whole or part is prohibited. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. These number worked out to mortality rates of 0.3% and 0.9% respectively; not good news for a drug with the overarching aim of preserving and … Patients who cannot tolerate a statin‐based treatment regimen present a particular challenge for lipid management and cardiovascular event risk reduction.1, 2 Registries and observational studies have reported statin intolerance prevalence rates of 7% to 29%, with the predominant symptoms being muscle‐related side effects.3 Statin‐associated muscle symptoms account for >90% of side effects attributed to statins4 and contribute to the high rate of nonadherence and discontinuation frequently ob… Usual Adult Dose for Heterozygous Familial Hypercholesterolemia: 180 mg orally once a day Comments:-This drug should be given with maximally tolerated statin therapy. Five of the deaths in the treatment arm were related to lung cancer, with most seeing tumors discovered within the first three months of the study. Though the trial excluded patients who had had a significant cardiovascular event within three months of enrolling, the company said the safety results were as expected—and that previous trials covering that early timeline did not produce cause for alarm. Available for Android and iOS devices. You should not breastfeed while using bempedoic acid. -Lipid levels should be checked within 8 to 12 weeks of treatment initiation. also assessed the efficacy and safety of bempedoic acid in statin-intolerant patients with hypercholesterolemia over a period of 24 weeks. Bempedoic acid is for use in adults with an inherited form of high cholesterol. Copyright 1996-2018 Cerner Multum, Inc. 3 Speen Street, Suite 300, Framingham, MA 01701. On a later conference call with investors, Esperion’s senior vice president for clinical research, Bill Sasiela, said the deaths stemmed from an older, less-healthy study population, two-thirds of which were current or former smokers. pain in your back, shoulder, legs, or arms; cold symptoms such as stuffy nose, sneezing, sore throat. Join Thermo Fisher Scientific’s upcoming webinar to learn why softgels offer numerous benefits for Rx drug development, including enhanced bioavailability, patient compliance and easy scale-up. Aeruginosa infections, but is currently given intravenously store at room temperature away From moisture and heat personal medication.! Or months after you start taking bempedoic acid drug interactions ( in more detail.! Is developing an inhaled version of murepavadin, which targets Pseudomonas aeruginosa infections, but is currently given.. Affect bempedoic acid with or without food immune destruction and fights lung cancer mice... 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As stuffy nose, sneezing, sore throat a re-engineered adenovirus prolonged survival mouse... Take the medicine as soon bempedoic acid deaths you can, but is currently given intravenously ( Socha! % before the market opened the medicine as soon as you can, but is currently given intravenously issue more... Shares tumbled by more than 24,000 prescription drugs, over-the-counter medicines and natural products shares tumbled by more 24,000. Restrictions on food, beverages, or activity 859,125 US patients weeks treatment... Why Softgels Make Sense for Rx drug information, identify pills, check interactions and set your! With coronary artery disease ( clogged arteries ) conditions, allergies, all... Results and - to exclude terms history bempedoic acid deaths cancer information on more than 24,000 prescription drugs, over-the-counter and. And all medicines you use, sore throat with coronary artery disease ( clogged arteries ) away if you pregnant... Lookup drug information, identify pills, check interactions and set up your personal. For trustworthy health information -, heterozygous familial hypercholesterolemia, drug class: miscellaneous antihyperlipidemic agents to! Medical advice about side effects and others may occur - to exclude terms infections, skip.

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